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Study identifies key factor in DNA damage associated with aging
In a recent study, Rochester scientists made two important contributions to DNA damage research. First, though scientists could previously point to an association between DNA damage and aging, the Rochester group has demonstrated a causal relationship between reduced DNA damage and extended lifespan. Second, the researchers have identified a cellular factor—an enzyme called topoisomerase 2, or Top2, implicated in DNA damage—that can be targeted to reduce that damage. The findings are published...
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| Categories: | Tags: Aging, Arts and Sciences, David Goldfarb, Department of Biology, DNA, research finding, replicative lifespan, aging, topoisomerase 2 poison, DNA damage, antagonistic pleiotropy | Comments: (0) | View Count: (915)
Epigenetic clock analyses of cellular senescence and ageing
A confounding aspect of biological ageing is the nature and role of senescent cells. It is unclear whether the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are descriptions of the same phenomenon instigated by different sources, or if each of these is distinct, and how they are associated with ageing.
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| Categories: | Tags: DNA methylation, ageing, senescence, DNA damage, radiation, Gerotarget | Comments: (0) | View Count: (1715)