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Microbes might thrive after crash-landing on board a meteorite
Bacteria riding on an incoming meteorite may be able to survive the violent shockwave created when it crash-lands on a planet. Their cell walls have been seen to rapidly harden and relax after a sudden shock compression, enabling them to bounce back even after an extreme collision.
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| Categories: | Tags: Bacteria, survival, pressure, reproduction | Comments: (0) | View Count: (1017)
Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury
Spermidine acts as an endogenous free radical scavenger and inhibits the action of reactive oxygen species.
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| Categories: | Tags: spermidine, retinal ganglion, cell survival, regeneration, mice, optic nerve, nerve injury | Comments: (0) | View Count: (1492)
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
Ironically, antiaging product advertisements often promise to “slow down the clock.” But abolishing the circadian clock—for example, by knocking out Bmal1, a core clock gene—accelerates aging and shortens the life span in mice. As a result, Bmal1 knockout mice often serve as a model system in studies of the role of circadian rhythms in the aging process. Now Yang et al. show that the developmental timing of Bmal1 expression influences the circadian clock’s effects on aging and survival.
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| Categories: | Tags: timing of expression, gene, Bmal1, aging, survival | Comments: (0) | View Count: (1445)
Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1
Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy metabolism. We hypothesized that in CR ghrelin has a role in protecting aging-related diseases.
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| Categories: | Tags: ghrelin signaling, survival, models of human, aging, sirtuin1 | Comments: (0) | View Count: (2321)