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03

The Hallmarks of Aging

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The Hallmarks of Aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and bioch...
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| Categories: | Tags: aging hallmarks, human pathologies, including cancer, diabetes, cardiovascular disorders, neurodegenerative diseases, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication | Comments: (0) | View Count: (980)
28

An epigenetic clock controls aging

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An epigenetic clock controls aging
We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control.
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| Categories: | Tags: senescence, programmed aging | Comments: (0) | View Count: (1099)
20

An epigenetic clock controls aging

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An epigenetic clock controls aging
We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control.
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| Categories: | Tags: Senescence, Programmed aging, Epigenetic, Evolution, Life history, Gene expression | Comments: (0) | View Count: (922)
Epigenetic clock analyses of cellular senescence and ageing
A confounding aspect of biological ageing is the nature and role of senescent cells. It is unclear whether the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are descriptions of the same phenomenon instigated by different sources, or if each of these is distinct, and how they are associated with ageing.
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| Categories: | Tags: DNA methylation, ageing, senescence, DNA damage, radiation, Gerotarget | Comments: (0) | View Count: (1467)
Evaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study
Purpose: Telomere attrition and corresponding cellular senescence of the retinal pigment epithelium contribute to the changes of age-related macular degeneration. Activation of the enzyme telomerase can add telomeric DNA to retinal pigment epithelium chromosomal ends and has been proposed as a treatment for age-related macular degeneration. We report the use of a small molecule, oral telomerase activator (TA)-65 in early macular degeneration. This study, focusing on early macular degeneration, p...
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| Categories: | Tags: drusen, macular degeneration, micro-perimetry, senescence, telomerase activation, telomere | Comments: (0) | View Count: (1597)
16

Aging shrinks chromosomes

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Aging shrinks chromosomes
A study on human cells reveals how cellular aging affects the 3-D architecture of chromosomes.
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| Categories: | Tags: senescence, genetics & genomics, epigenetics, disease/medicine, chromatin, cell & molecular biology and aging | Comments: (0) | View Count: (1227)
09

PRMT7 preserves satellite cell regenerative capacity

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PRMT7 preserves satellite cell regenerative capacity
PRMT7 is required for muscle stem cell self-renewal and regenerative capacity in vivo. PRMT7 deletion causes senescence of activated muscle stem cells. This entry into senescence is associated with persistent expression of p21.
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| Categories: | Tags: PRMT7, muscle regeneration, senescence, aging, DNMT3b, p21CIP1, muscle stem cell | Comments: (0) | View Count: (1405)