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Popular belief that saturated fats clog up arteries 'plain wrong', say experts
The widely held belief among doctors and the public that saturated fats clog up the arteries, and so cause coronary heart disease, is just "plain wrong,"
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| Categories: | Tags: diet, obesity, saturated fat, heart, cardiovascular system | Comments: (0) | View Count: (1144)
03

The Hallmarks of Aging

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The Hallmarks of Aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and bioch...
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| Categories: | Tags: aging hallmarks, human pathologies, including cancer, diabetes, cardiovascular disorders, neurodegenerative diseases, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication | Comments: (0) | View Count: (1262)
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Jennifer Doudna: How CRISPR lets us edit our DNA

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Jennifer Doudna: How CRISPR lets us edit our DNA
TED Talk Subtitles and Transcript: Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits to DNA strands, which could lead to treatments for genetic diseases ... but could also be used to create so-called "designer babies." Doudna reviews how CRISPR-Cas9 works -- and asks the scientific community to pause and discuss the ethics of this new tool.
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| Categories: | Tags: called CRISPR-Cas9, Doudna, TED | Comments: (0) | View Count: (1918)
Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan
Summary Compartmentalization of the gastrointestinal (GI) tract of metazoans is critical for health. GI compartments contain specific microbiota, and microbiota dysbiosis is associated with intestinal dysfunction. Dysbiosis develops in aging intestines, yet how this relates to changes in GI compartmentalization remains unclear. The Drosophila GI tract is an accessible model to address this question. Here we show that the stomach-like copper cell region (CCR) in the middle midgut controls distri...
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| Categories: | Tags: age-related, compartmentalization, microbiota dysbiosis, lifespan | Comments: (0) | View Count: (1668)
Patient-specific age: the other side of the coin in advanced mesenchymal stem cell therapy
Multipotential mesenchymal stromal cells (MSC) are present as a rare subpopulation within any type of stroma in the body of higher animals. Prominently, MSC have been recognized to reside in perivascular locations, supposedly maintaining blood vessel integrity. During tissue damage and injury, MSC/pericytes become activated, evade from their perivascular niche and are thus assumed to support wound healing and tissue regeneration. In vitro MSC exhibit demonstrated capabilities to differentiate in...
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| Categories: | Tags: vascular niche, cell-based therapy, aging biology, cellular dysfunction, age-associated pathology, regenerative medicine | Comments: (0) | View Count: (1895)
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Drug prevents age related brain changes in rats

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Drug prevents age related brain changes in rats
As brain cells age they lose the fibers that receive neural impulses, a change that may underlie cognitive decline. Researchers at the University of California, Irvine recently found a way to reverse this process in rats. The study was published Feb. 3, 2016 in The Journal of Neuroscience. Researchers caution that more studies are needed, but the findings shed light on the mechanisms of cognitive decline and identify potential strategies to stem it.
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| Categories: | Tags: drag, age-related changes, brain, rats | Comments: (0) | View Count: (1568)
05

Drug prevents key age-related brain change in rats

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Drug prevents key age-related brain change in rats
As brain cells age they lose the fibers that receive neural impulses, a change that may underlie cognitive decline. Researchers at the University of California, Irvine recently found a way to reverse this process in rats. The study was published Feb. 3, 2016 in The Journal of Neuroscience. Researchers caution that more studies are needed, but the findings shed light on the mechanisms of cognitive decline and identify potential strategies to stem it.
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| Categories: | Tags: drug, age-related, rats, brain change | Comments: (0) | View Count: (1557)