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Long-read genome sequencing used for the first time in a patient
Researchers have used a next-generation technology called long-read sequencing to diagnose a patient's rare genetic condition that current technology failed to diagnose.
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| Categories: | Tags: Genetics, diagnostics, DNA sequencing, DNA | Comments: (0) | View Count: (872)
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How cells combat chromosome imbalance

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How cells combat chromosome imbalance
Biologists have now identified a mechanism that the immune system uses to eliminate genetically imbalanced cells from the body.
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| Categories: | Tags: Genetics, karyotype, immune system, immunity, DNA, cancer, oncology | Comments: (0) | View Count: (765)
Gene editing strategy eliminates HIV-1 infection in live animals
A permanent cure for HIV infection remains elusive due to the virus's ability to hide away in latent reservoirs. But now, scientists show that they can excise HIV DNA from the genomes of living animals to eliminate further infection.
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| Categories: | Tags: HIV, genetics, genetic engineering, genome modification, DNA, CRISPR/CAS9 | Comments: (0) | View Count: (593)
Octopuses can basically edit their own genes on the fly
Crazy levels of RNA tinkering could explain how cephalopods got so smart
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| Categories: | Tags: genetics, genome modification, gene engineering, octopuses, DNA recombination, RNA recombination | Comments: (0) | View Count: (639)
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Scientists unveil a giant leap for anti-aging

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Scientists unveil a giant leap for anti-aging
UNSW researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.
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| Categories: | Tags: aging reverse, anti-aging drug, protein, NAD+, radiation protection, DNA protection | Comments: (0) | View Count: (1112)
Study identifies key factor in DNA damage associated with aging
In a recent study, Rochester scientists made two important contributions to DNA damage research. First, though scientists could previously point to an association between DNA damage and aging, the Rochester group has demonstrated a causal relationship between reduced DNA damage and extended lifespan. Second, the researchers have identified a cellular factor—an enzyme called topoisomerase 2, or Top2, implicated in DNA damage—that can be targeted to reduce that damage. The findings are published...
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| Categories: | Tags: Aging, Arts and Sciences, David Goldfarb, Department of Biology, DNA, research finding, replicative lifespan, aging, topoisomerase 2 poison, DNA damage, antagonistic pleiotropy | Comments: (0) | View Count: (537)
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Jennifer Doudna: How CRISPR lets us edit our DNA

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Jennifer Doudna: How CRISPR lets us edit our DNA
TED Talk Subtitles and Transcript: Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits to DNA strands, which could lead to treatments for genetic diseases ... but could also be used to create so-called "designer babies." Doudna reviews how CRISPR-Cas9 works -- and asks the scientific community to pause and discuss the ethics of this new tool.
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| Categories: | Tags: called CRISPR-Cas9, Doudna, TED | Comments: (0) | View Count: (1343)
Epigenetic clock analyses of cellular senescence and ageing
A confounding aspect of biological ageing is the nature and role of senescent cells. It is unclear whether the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are descriptions of the same phenomenon instigated by different sources, or if each of these is distinct, and how they are associated with ageing.
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| Categories: | Tags: DNA methylation, ageing, senescence, DNA damage, radiation, Gerotarget | Comments: (0) | View Count: (1142)
Blood epigenetic age may predict cancer incidence and mortality
Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are chronologically.
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| Categories: | Tags: epigenetic age, cancer risk, DNA methylation | Comments: (0) | View Count: (1203)